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Villous adenoma

MedGen UID:
60206
•Concept ID:
C0206674
•
Neoplastic Process
Synonyms: Adenoma, Villous; Adenomas, Villous; Villous Adenoma; Villous Adenomas
SNOMED CT: Villous papilloma (128859003); Villous adenoma (128859003)
 
Monarch Initiative: MONDO:0000502

Definition

An adenoma arising from the glandular epithelium of the gastrointestinal tract. It is characterized by the presence of a villous architectural pattern. Most often it occurs in the large intestine, small intestine, and the stomach. The neoplastic epithelial cells show dysplastic features. [from NCI]

Professional guidelines

PubMed

Double balloon enteroscopy in children: diagnosis, treatment, and safety.
Thomson M, Venkatesh K, Elmalik K, van der Veer W, Jaacobs M
World J Gastroenterol 2010 Jan 7;16(1):56-62. doi: 10.3748/wjg.v16.i1.56. PMID: 20039449Free PMC Article
Intestinal invagination in adults: preoperative diagnosis and management.
Martín-Lorenzo JG, Torralba-Martinez A, Lirón-Ruiz R, Flores-Pastor B, Miguel-Perelló J, Aguilar-Jimenez J, Aguayo-Albasini JL
Int J Colorectal Dis 2004 Jan;19(1):68-72. Epub 2003 Jun 28 doi: 10.1007/s00384-003-0514-z. PMID: 12838363
Duodenal polyps: diagnosis and management.
Reddy RR, Schuman BM, Priest RJ
J Clin Gastroenterol 1981 Jun;3(2):139-47. doi: 10.1097/00004836-198106000-00007. PMID: 7240690

Recent clinical studies

Etiology

Association between Helicobacter pylori infection and colorectal polyps.
Basmaci N, Karataş A, Ergin M, Dumlu GŞ
Medicine (Baltimore) 2023 Oct 20;102(42):e35591. doi: 10.1097/MD.0000000000035591. PMID: 37861565Free PMC Article
Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
Clonality of combined tumors.
Huang J, Behrens C, Wistuba II, Gazdar AF, Jagirdar J
Arch Pathol Lab Med 2002 Apr;126(4):437-41. doi: 10.5858/2002-126-0437-COCT. PMID: 11900568
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Diagnosis

Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
The third pathway of colorectal carcinogenesis.
Rubio CA, Puppa G, de Petris G, Kis L, Schmidt PT
J Clin Pathol 2018 Jan;71(1):7-11. Epub 2017 Jul 27 doi: 10.1136/jclinpath-2017-204660. PMID: 28751521
Rectal pseudodiverticulum.
Singh S, Savage L
BMJ Case Rep 2014 Jul 8;2014 doi: 10.1136/bcr-2013-201888. PMID: 25006050Free PMC Article
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Therapy

Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
Rectal pseudodiverticulum.
Singh S, Savage L
BMJ Case Rep 2014 Jul 8;2014 doi: 10.1136/bcr-2013-201888. PMID: 25006050Free PMC Article
Laparoscopic total mesorectal excision (TME) for rectal cancer surgery: long-term outcomes.
Leroy J, Jamali F, Forbes L, Smith M, Rubino F, Mutter D, Marescaux J
Surg Endosc 2004 Feb;18(2):281-9. Epub 2003 Dec 29 doi: 10.1007/s00464-002-8877-8. PMID: 14691716
In situ adenocarcinoma of the bladder.
Chan TY, Epstein JI
Am J Surg Pathol 2001 Jul;25(7):892-9. doi: 10.1097/00000478-200107000-00007. PMID: 11420460
Experience with the use of the circular stapler in rectal surgery.
Kyzer S, Gordon PH
Dis Colon Rectum 1992 Jul;35(7):696-706. doi: 10.1007/BF02053764. PMID: 1611960

Prognosis

Gastric villous adenoma: a case report and review of the literature.
Sathirawich P, Pongpaibul A, Parakonthun T, Kaosombatwattana U
J Med Case Rep 2023 Apr 26;17(1):167. doi: 10.1186/s13256-023-03893-2. PMID: 37098577Free PMC Article
Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.
Bains L, Lal P, Vindal A, Singh M
World J Surg Oncol 2019 Jun 25;17(1):109. doi: 10.1186/s12957-019-1650-4. PMID: 31238922Free PMC Article
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698
Pancreas-sparing duodenectomy: technique and indications.
Lundell L, Hyltander A, Liedman B
Eur J Surg 2002;168(2):74-7. doi: 10.1080/11024150252884278. PMID: 12113274
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Clinical prediction guides

Association between Helicobacter pylori infection and colorectal polyps.
Basmaci N, Karataş A, Ergin M, Dumlu GŞ
Medicine (Baltimore) 2023 Oct 20;102(42):e35591. doi: 10.1097/MD.0000000000035591. PMID: 37861565Free PMC Article
Villous Adenoma Arising in the Urethra of a Female with Bladder Augmentation History: A Case Report and Review of the Literature.
Demir H, Cin S, Citgez S, Uygun N
Turk Patoloji Derg 2021;37(2):161-166. doi: 10.5146/tjpath.2020.01502. PMID: 32779155Free PMC Article
Reliability in villous tumors staging between preoperative MRI and histopathological examination.
Vogrig C, Leclerc J, Haghnejad V, Orry X, Remen T, Germain A, Laurent V
Abdom Radiol (NY) 2020 Oct;45(10):3046-3056. doi: 10.1007/s00261-020-02450-5. PMID: 32123949
Updates in the Pathologic Diagnosis and Classification of Epithelial Neoplasms of Urachal Origin.
Paner GP, Lopez-Beltran A, Sirohi D, Amin MB
Adv Anat Pathol 2016 Mar;23(2):71-83. doi: 10.1097/PAP.0000000000000110. PMID: 26849813
Magnification chromo-colonoscopy.
Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

Recent systematic reviews

Incidence of advanced adenomas at surveillance colonoscopy in patients with a personal history of colon adenomas: a meta-analysis and systematic review.
Saini SD, Kim HM, Schoenfeld P
Gastrointest Endosc 2006 Oct;64(4):614-26. doi: 10.1016/j.gie.2006.06.057. PMID: 16996358
Endorectal ultrasound detection of focal carcinoma within rectal adenomas.
Worrell S, Horvath K, Blakemore T, Flum D
Am J Surg 2004 May;187(5):625-9; discussion 629. doi: 10.1016/j.amjsurg.2004.01.005. PMID: 15135679

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